Genetic characterisation of vancomycin resistant isolates of Enterococcus faecium isolated from patients in Tehran

Abstract number: P1668

Feizabadi M., Fatollahzadeh B., Sayadi S., Parvin M.

Objectives: We have previously found that up to 12% of clinical isolates of E. faecium at Tehran hospitals showed resistance to vancomycin. However, little data was available on the genetic heterogeneity of vancomycin resistant isolates (VRE) among the Iranian population of this organism. Therefore the emergence of infections with the new clones of VRE needs to be investigated.

Materials and Methods: Collectively, 103 non replicative isolates of enterococci grown from urine samples in the first quarter of 2005 were screened for their susceptibilities to different antibiotics. Ribotyping was then used to genetically characterize the isolates of VRE.

Results: Using disk diffusion method, all isolates were found susceptible to linezolid and nitrofurantoin. All isolates of E. faecalis (n = 86) were susceptible to vancomycin. Conversely, over 70% of E. faecium isolates (n = 12) showed resistance to this glycopepide. The VRE isolates recovered from patients in 2005 were heterogenous comparing with those of 2000.

Conclusion: Conventional bacteriology confirmed the increase in rate of VRE. It appears that a variety of new VRE clones have arisen recently at different wards of this hospital as determined by ribotyping.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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