Invasive aspergillosis in haematological patients by exposure to laminar air flow: description of 65 cases between 2004 and 2006

Abstract number: P1577

Nicolle M.C., Thiebaut A., De Monbrison F., Voirin N., Thomas X., Nicolini F.E., Perraud M., Picot S., Vanhems P., Michallet M.

Objectives: Invasive aspergillosis (IA) occurred mainly in immunosuppressed patients (pts) with intensive chemotherapy and/or auto-or allogeneic hematopoietic stem cell transplantation. The objective was to describe IA and related care for pts hospitalised (+) or not (-) in a room with laminar air flow (LAF).

Methods: Proven and probable cases of IA (EORTC criteria) were collected prospectively between 01/01/2004 and 31/12/2006 in a university hospital and validated monthly by a multidisciplinary team. The demographic characteristics, the risk factors, clinical and mycological features and CT-scan reports were analysed.

Results: 65 IA were identified with a median age of 56 years.

Conclusion: Delay of onset between admission and diagnosis is similar between pts hospitalised in LAF rooms or not. The hypothesis on a fungal carriage before admission can be discussed considering environmental controls of Aspergillus contamination performed quarterly for each LAF room were satisfactory. The care management (CT-scans and mycological sample) was similar between the 2 groups of pts.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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