Fungiscope – first Romanian multicentre study on fungaemia: preliminary results

Abstract number: P1570

Mares M., Flonta M., Almas A., Dan M., Cirlan M., Bazgan O., Malic L.I., Dorneanu O., Coman G., Buiuc D.

Objectives: This paper presents the preliminary results of a multicentre study on fungaemia made under auspices of the Romanian Society of Medical Mycology and Mycotoxicology in four tertiary hospitals from Iasi and Cluj-Napoca (Romania) between 2002 and 2007. The aim of this study is to evaluate the species distribution of fungal strains isolated from bloodstream cultures.

Methods: The study has included a total number of 3896 blood cultures from patients hospitalised in departments of cardiovascular surgery, general surgery, intensive care and infectious diseases. The range of age varied between 12 days and 82 years. The major clinical sign which required the bloodstream cultures has been the persistent fever. The presence of an intravenous central catheter, invasive surgery and previous broad spectrum antibiotic therapy have been the most frequent risk factors. In order to detect the fungal strains we used the Hemoline Performance Duo bottles, the BacT/ALERT®FA bottles, and the BacT/ALERT Microbial Detection System. The isolated strains have been identified on the basis of morphological and biochemical features, using specific tests.

Results: The percentage of fungaemia was 1.54% (60 positive blood cultures). The frequency of fungal species implied in fungaemia aetiology was: Candida albicans 35%, C. parapsilosis 15%, C. tropicalis 5%, C. pelliculosa 5%, C. krusei 5%, C. sake 5%, C. glabrata 3.33%, C. dubliniensis 1.66%, C. norvegensis 1.66%, C. norvegica 1.66%, C. kefyr 1.66%, C. intermedia 1.66%, C. valida 1.66%, C. famata 1.66%, C. guilliermondii 1.66%, Rhodotorula glutinis 3.33%, Cryptococcus neoformans 1.66%, Trichosporon asahii 1.66%, Acremonium spp. 3.33%, Pseudallescheria boydii 1.66% and Fusarium solani 1.67%.

Conclusions: The rate of positive blood cultures emphasising fungaemia is still low comparatively with those exhibiting bacterial infections. The study underlines the diversity of fungal strains isolated from bloodstream cultures. It can be noted a relatively low frequency of Candida albicans strains and the emergence of fungaemia due to non-albicans species accordingly to worldwide trends. More studies are necessary in order to evaluate the antifungal susceptibility profile, especially in species with high risk for resistance to usual antifungal drugs.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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