Epidemiological and clinical features of 85 patients with tuberculosis at a teaching hospital in Italy
Abstract number: P1555
Bonadio M., Vetrano U., Garzelli C., Virgone E., Carneglia L.
Background: A previous similar study performed at the same institution (Hospital of Pisa) during the 19962000 period showed a TB incidence ranging from 8.5 to 6.8 (N/100.000), a rate of extrapulmonary TB of 24.5% and a 3.8% frequency of isolates resistant to 2 drugs.
Aim of the study and methods: In order to describe current epidemiologic and clinical features of patients with TB identified in the hospital of Pisa (Italy), a retrospective study of all cases of TB notified to the Local Public Health Service during January 2004 December 2006 was performed. The diagnosis of TB was made following the criteria of the WHO.
Results: A total of 85 patients (M 39, F 46) affected by TB were identified. Diagnosis was microbiologically proved in 81 patients. Thirty-five patients were immigrants (mostly from East-Europe and South-East Asia). The incidence of TB (N/100.000) was 9.5, 8.0 and 7.0 in 2004, 2005 and 2006, respectively. 66.5% of patiens had pulmonary TB; 33.5% of patients had extrapulmonary or mixed TB.
Extrapulmonary TB was more frequent in immigrant patients (42.8%) than in italian ones (22%). Five patients were presenting advanced HIV infection. Microscopic examination for acid fast bacilli in sputum or bronchial secretion resulted negative in 67.3% of colture proved pulmonary TB.
7% of the isolated strains of M.tubercolosis were resistant to 2 drugs.
Conclusions: The incidence of TB observed in the present study seems to be similar to that observed at our institution during the 19962000 period. The rate of extrapulmonary TB shows a trend to increase expecially in immigrant patients.
The isolation rate of resistant strains to drugs of M. tuberculosis in our geographical area shows an increasing trend.
|Session name:||18th European Congress of Clinical Microbiology and Infectious Diseases|
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