Community-associated meticillin-resistant Staphylococcus aureus: prospective surveillance of prevalence and clinico-epidemiologic feature among patients with otorrhoea in primary Korean otolaryngology clinic

Abstract number: P1443

Lee J., Park C.W., Seo Y.B., Song J.Y., Hwang I.S., Cheong H.J., Kim W.J.

Objectives: Community-associated meticillin-resistant Staphylococcus aureus(CA-MRSA) has emerged as an important infection in the community setting. Most of CA-MRSA infections in Korea are ear infection(acute ear infection, chronic otitis media), but little is known about the epidemiology of CA-MRSA in primary otolaryngologic clinics. To determine the prevalence, and clinical and microbiological characteristics of CA-MRSA in ear infection of community setting, we designed a prospective survey. We also investigated the analysis of clonal relatedness of CA-MRSA from five different clinics.

Methods: From January to June, 2007, 178 otorrhoea samples were collected from five clinics in west area of Seoul and were classified MRSA or not. A comparative analysis of risk factors for CA-MRSA infection was performed. SCCmec typing by multiplex PCR, molecular typing by pulsed-field gel electrophoresis(PFGE) and multi-locus sequence typing(MLST) were done with MRSA isolates.

Results: Proportion of MRSA was 36.7%(33/90) and was significantly different between 5 clinics(p < 0.01). Recent antibiotic use was most significant risk factor for MRSA infection(p < 0.01). SCCmec type II isolates were most prevalent(63.6%, 21/33) and type IV isolates were 21.2%(7/33). 8 MLST types were discovered. Among them, 4 types(ST83, 639, 509, 627) were newly discovered in Korea. Same PFGE type was discovered in different clinics. Some MRSA isolates had a similar or same PFGE types in clinic of high MRSA rate.

Conclusion: This study demonstrates that CA-MRSA infection was prevalent and variable MRSA clones were epidemic in otolaryngologic clinics of community. Most of MRSA isolates had molecular characteristics of hospital-associated MRSA(HA-MRSA) and some others had molecular characteristics of CA-MRSA.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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