Bloodstream infections after solid-organ transplantation

Abstract number: P1136

Serin Senger S., Kursun E., Kurt Azap O., Timurkaynak F., Arslan H.

Objectives: Analyzing the characteristics of bloodstream infections occurring in solid organ transplantation (SOT) recipients.

Methods: All bacteraemia among SOT recipients in our institution during the period from January 2002 to December 2007 were included in the study. We performed a retrospective chart review to determine the patient data such as age, gender, the duration from transplantation to a diagnosis of BSI, whether the BSI was hospital- or community-acquired. The primary BSI was defined as the bacterium isolated from blood culture, which is not related to an infection at another site. Otherwise it was defined as secondary BSI.

Results: A total number of 58 BSI episodes in 42 patients were diagnosed. Of these patients 11 (26.2%) were female. The ages of the patients were in the range 18 to 68 years, with a mean value of 42.1. There were 30 liver, 11 kidney, and one liver-kidney recipients. Of the episodes 17 (in 13 liver and 3 kidney recipients) were diagnosed within the first month after the transplantation, 22 (in 10 liver and 2 kidney recipients) during the 1–6 months period, and 19 (in 7 liver, 6 kidney, and one liver-kidney recipients) after the sixth month. Of the episodes 10 were primary. The most common focus of BSI was abdominal among liver recipients with 35 (97.2%) episodes, whereas it was urinary among kidney recipients with 6 (54.5%) episodes. Escherichia coli was the most frequent agent in both groups of recipients. Two episodes were polybacterial. The list of causative agents was shown in the Table.

Table: Frequencies of causative agents of BSI among SOT recipients

Conclusion: The number of BSI episodes was highest in the period of 1 to 6 months after the SOT. Secondary BSIs were considerably more frequent than the primary BSIs. The leading foci of secondary BSIs were consistent with the region of transplantation; that is abdominal for liver, whereas urinary for kidney SOT.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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