The natriuretic peptide (BNP) as a marker of sepsis

Abstract number: P1076

Petrocheilou C., Karaferi A., Pouyiouka M., Karabasi V., Achilleos C., Nitsa A., Toutouza M.

Objective: The discovery of a reliable marker for sepsis is of great significance for the on time management and survival of septic patients. The aim of the study is the evaluation of the reliability of the Natriuretic peptide (BNP) as a marker of sepsis in comparison to C Reactive protein.

Methods: We studied 58 patients of the ICU in a year period. They were separated into 2 groups. Group A with 8 non septic patients and Group B with 50 patients suffering from great sepsis and septic shock. Blood samples were taken from all patients at their admittance and at days 2, 3, 4, 6, 8 and 10. The levels of BNP were analysed with microsomatic immunoenzyme method (AXSYM – ABBOT) (Normal value <100 pg/ml) and the levels of CRP with nefelometry (Normal value <5 mg/ l).

Patients with heart failure were excluded from the study.

Results: The mean value of BNP in Group A was 24.2 pg/ml, while the mean value of BNP in Group B was 971.2 pg/ml. The difference is statistically important.

The mean value of CRP in Group A was 103.3 mg/l, while in Group B it was 107.062 mg/l. The difference has no statistical importance.

Conclusion: The evaluation of the results seem to drive to the conclusion that the levels of BNP are reliably increased in patients with great sepsis and septic shock and may be a valuable diagnostic tool.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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