Trend of prevalence of human immunodefiency virus type 1(HIV-1) non-B aubtypes in Galicia, northwestern Spain
Abstract number: P1012
Rodriguez-Calviño J., Cortizo-Vidal S., Rodriguez-Otero L., Gutierrez D., Romero-Jung P., Prieto A., Varela E., Aguilera-Guirao A., Regueiro B.
Objectives: HIV-1 non-B subtypes plays an important role in the HIV epidemic and its prevalence has increased throughout the years. Understanding the cause of this increase is important for public health strategies. The aim of this study was to observe the trend of prevalence of HIV-1 non B genotypes in Galicia (North West of Spain) between 2003 and 2007.
Methods: In a prospective study in Santiago de Compostela, from a total of 322 newly diagnosticated HIV patients, we defined subtypes by partial sequencing of the polimerase gene by means of automated sequencing (CEQ 2000 system, Beckman Coulter Inc) and phylogenetic analysis using the geno2pheno program (Max Planck Institut Informatic, http://www.geno2pheno.org).
Results: The subtype B was the most frequently isolated. The non-B subtypes proportion found between our patients were the following: non recombinant subtypes A, C, D, F and G (45.83%) and recombinant subtypes AE, AG, BF and BG (54.17%). Subtypes AG and D were the most prevalent and there were no diferences in relatives frequences of recombinant and non recombinant subtypes over the years. In newly diagnosticated HIV patients, the prevalence of non-B subtype viruses was: 3.17% in 2003, 2.59% in 2004, 1.49% in 2005, 12.72% in 2006 and 11.66% in 2007.
Conclusion: The present data suggest that a significant trend to higher prevalence in patients infected with non-B subtypes was observed and it became more intense for the two last years; however, HIV subtype B is still the most commonly found. On the other hand, comparing between the non-B subtypes we conclude that there are a similar proportion of recombinant and non recombinant non-B sybtypes.
|Session name:||18th European Congress of Clinical Microbiology and Infectious Diseases|
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