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Factors associated with presence of isolated anti-HBc antibody in HIV-infected persons in Taiwan

Abstract number: P1005

Hung C-C., Ko W-C., Tsai J-J., Liu C-E., Wong W-W., Su S-C., Ho M-W., Cheng S-H., Yang C-H., Lin Y-H., Miao W-J.

Objectives: To determine factors associated with presence of isolated anti-HBc antibody (positive anti-HBc antibody with negative HBsAg and anti-HBs antibody) in HIV-infected persons in Taiwan where the prevalence of chronic hepatitis B virus (HBV) infection is 15–20% in the general population aged 25 years or greater and vertical transmission is the major transmission route for HBV.

Methods: Clinical characteristics of 403 HIV-infected persons aged 15 years or greater who had an isolated anti-HBc antibody pattern were compared with those of 943 HIV-infected persons who developed protective HBV immunity after HBV exposure (negative HBsAg; positive anti-HBs and anti-HBc antibody). HBV DNA was measured in 68 persons with isolated anti-HBc antibody who had available serum specimens. Among these 68 persons in whom 45 persons had available anti-HBs titers, the relationship between HBV DNA load and anti-HBs titer levels were analysed.

Results: In univariate analysis, factors associated with presence of isolated anti-HBc antibody included older age (41 vs. 37 years, p<0.001), sexual transmission route (66.6 vs. 60.1%, p = 0.033), lower median CD4 counts (203 vs. 295 cells/mgL, p<0.001), and high plasma HIV RNA load (4.65 vs. 4.44 log10 copies/mL, p = 0.008); HCV seropositivity and intravenous drug use were not independent associated factors. In multivariate analysis, independent associated factors were age (odds ratio, 1.022, 95% CI 1.011–1.034) and a CD4 count less than 100 cells/mgL (odds ratio, 1.605, 95% CI 1.236–2.083). Among the 68 persons with isolated anti-HBc antibody and HBV DNA measurement, 14.7% had detectable HBV DNA. Of the 45 persons with isolated anti-HBc antibody who had determinations of both anti-HBs antibody titers and HBV DNA load, 38 (84.4%) had titers between 1 and 10 mIU/mL. Only 13.2% of these 38 persons had detectable HBV DNA while 28.6% of the 7 persons with anti-HBs titer less than 1 mIU/mL had detectable HBV DNA load (p = 0.296).

Conclusion: We concluded that, different from what have been reported by investigators in the Western countries that chronic HCV infection is associated with isolated anti-HBc antibody pattern, age and CD4 counts lower than 100 cells/£gL were associated with presence of isolated anti-HBc antibody in HIV-infected persons in Taiwan, and compromised immunity with subsequently waning of anti-HBs titers might play a role.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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