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Paediatric Chagas' disease in a non-endemic area

Abstract number: P972

Juncosa T., Fumadó V., Sanllorente M., Aguilar A., Pino R.

Objectives: During last years, increasing migration from Central and South America, the endemic area of Chagas Disease, has introduced among our paediatric population some patients infected by T. cruzi, infected either in their origin country or in ours, via vertical transmission from their infected mothers. The objective of this study is to describe the cases of children with Chagas Disease attended at our Imported Pathology Unit during the last four years (2003–2007).

Methods: All patients coming from endemic areas and newborns from Chagas Disease seropositive pregnant women, were studied by two ELISA tests (Bioelisa Chagas BiokitR with recombinant antigens and in-house ELISA with complete antigens). Patients with available sample (59) were also screened by nested PCR (TCZ3/Z4). Confirmed cases received Benznidazol treatment (0.7 mg/Kg/day during 60 days).

Results: Screening was performed to 155 patients, aged one day to 13 years old (110 immigrants and 45 born in Spain). Ten of them were seroreactive in both ELISA tests (6.45%) and we had enough blood from five of them for PCR tests, which were positive for all samples. Vertical transmission was demonstrated in two children born in our country, one from a Bolivian mother and the other from an Argentina's one. The eight immigrated children were born in Bolivia. Follow up is in course in eight out of the ten seroreactive patients (two of them didn't continue attending our hospital) in order to establish the effectiveness of treatment. Negative PCR and decreasing specific antibodies have been demonstrated in all studied patients.

Discussion: Our results demonstrate a seroprevalence for T. cruzi infection of 7.2% (8/110) among the paediatric immigrated population coming from Latin America, and an incidence of congenital infection of 4.4% (2/45). Both percentages are high enough to encourage serologic screening for Chagas Disease to all children coming from Latin America, mainly from Bolivia. Post treatment serologic control must continue until antibodies level become negative. We have demonstrated titles decrease, but negativisation has not been assumed in any case.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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