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Serological screening of Chagas' disease in pregnant immigrant women proceeding from endemic areas in Spain

Abstract number: P971

Alonso P., Rodríguez-Guardado A., Rodríguez M., Escudero A., Vega E., Leiva P., Cartón J.

Objectives: Maternal-fetal transmission of Trypanosoma cruzi generally occurs in 2–12% of pregnant infected mothers. The arrival of pregnant women proceeding from endemic areas to non-endemic countries due to immigration phenomenon make possible the apparition of this diseases in this group of patients. The possibility of congenital infection in pregnant immigrant women in non-endemic areas has been studied only occasionally.

Methods: We determined anti-T. cruzi antibodies in all the pregnant immigrant women proceeding from endemic areas attending in obstetric service of Hospital Central de Asturias, a universitary hospital in the Northern of Spain, from 07/03/07 to 23/10/07. The ID-Chagas antibody test (Particle Gel Immuno Assay – PaGIA, DiaMed-ID –) was used as screening assay: red coloured polymer particles are sensitised with three different peptides representing antigenic sequences of T. cruzi.

Results: During the period of the study we screened 103 pregnant women (mean age 29 years, limits 17–43). The countries of origin were: Ecuador (32.0%), Colombia (17.5%), Brazil (15.5%), Paraguay (9.7%), Dominican Republic and in a minor percentage Venezuela (5.8%), Argentina (2.9%), Bolivia (2.9%), Cuba (1.9%) and Mexico (0.97%). Sixty patients lived in urban areas and 24 in rural areas. In 20 patients the characteristics of the living place was unknown. Only five patients lived in houses where the reproduction of triatomine bugs is possible. Two patients had family history of Chagas' disease. None patients presented positive antibodies anti-Trypanosoma cruzi.

Conclusions: Although the pregnant women arrival of endemic areas, no case of Chagas' disease was detected, probably due to the absence of epidemiological risk factors. Undoubtedly further studies of large samples are necessary to evaluate maternal transmission risk in immigrant population in Spain.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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