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IL-17 is associated with severity of invasive meningococcal disease

Abstract number: P951

Beran O., Dzupova O., Lawrence D., Holub M.

Objectives: The aim of the present study was to determine the cytokine profile of plasma and cerebrospinal fluid (CSF) during invasive meningococcal disease (IMD) with use of a multiplex system. The relationship between cytokine concentrations and IMD severity was also assessed.

Methods: A total of 12 patients with IMD were evaluated. Paired plasma and CSF samples were obtained at the time of diagnostic (day 1) and follow-up (day 3–5) lumbar puncture (LP). Plasma and CSF concentrations of 11 biomarkers (TNF-a, IL-1b, IL-6, IL-8, IL-10, IL-12, IL-17, MCP-1, MIP-1b, IL-1Ra, leptin) were analysed using a Luminex® analysis. Disease severity was evaluated using Acute Physiology and Chronic Health Evaluation (APACHE) II score, Sequential Organ Failure Assesment (SOFA) score and Glasgow Coma Scale (GCS) score.

Results: Plasma concentrations of IL-6, IL-10, IL-17 and IL-1Ra were associated with APACHE II on day 1. With regard to the severity of organ dysfunction on day 1, plasma IL-6, IL-8 and IL-10 concentrations showed the best correlation with SOFA. Unlike plasma cytokines, CSF concentrations were not associated with the disease severity.

Conclusion: Multiple cytokine analysis revealed cytokine patterns associated with inflammatory response during IMD. Moreover, the study is first to demonstrate that the increased IL-17 plasma concentration is associated with IMD severity. Since IL-17 is mainly produced by a CD4+ T cell subset (Th17 cells), our results suggest an important role of these cells in the IMD pathophysiology. Acknowledgement. The study is supported by a grant IGA NR/9316–3.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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