Empirical first-line antibiotic-therapy in adult patients with acute upper respiratory tract infections in eastern part of Poland

Abstract number: P849

Panasiuk L., Lukas W., Skorupka J.

Objectives: The main objective of the study was the evaluation of the frequency and the verification of appropriateness of the use of antibiotics in empirical first-line therapy in adult patients with acute upper respiratory tract infections. In addition, the aim of the study was to discover whether there are any differences in the amount of antibiotics prescribed according to the place of residence (urban, rural), gender and age.

Methods: The analysis covered medical records of 4,047 patients from 47 health centres in the Lublin Region (eastern part of Poland) concerning the period of one year – 1 September 2005 – 31 August 2006. From among all the diagnoses, only newly diagnosed cases of acute upper respiratory tract infections were selected in patients who had no medical history of chronic respiratory diseases. Age, gender, and place of residence of patients were recorded, as well as the fact of prescribing or not prescribing an antibiotic by a physician during the first visit, and the type of antibiotic used.

Results: The documentation contained the records concerning 1,386 visits, the reason for which was qualified by physicians as acute infection of the upper respiratory tract. Acute pharyngitis and tonsillitis, acute respiratory tract infections of multiple and unspecified sites, a common cold, and acute bronchitis were the most frequent diagnoses made. While analysing all the cases it was noted that antibiotics were applied in empirical first-line therapy in 1,103 cases, which constituted 79.58% of the total number of morbid cases. The antibiotics most frequently used were: amoxicillin (26.77%), amoxicillin with clavulanic acid (13.1%), macrolides (12.5%), and doxycycline (10.5%). No statistically significant differences in the use of antibiotics were observed according to patients' age, gender, and place of residence.

Conclusions: The analysis showed that in the great majority of cases the use of antibiotics was inappropriate. If this situation persists, in the near future it will lead to an increase in the phenomenon of antibioticoresistance in Poland. In order to prevent this situation, it is necessary to carry out an extensive educational action concerning the hazardous effect of excessive use of antibiotics, both among physicians and the whole society.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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