Diabetes, glycaemic control and risk of hospitalisation with pneumonia: a population-based case-control study
Abstract number: P835
Kornum J.B., Thomsen R.W., Riis A., Lervang H., Schønheyder H.C., Sørensen H.T.
Objective: To examine whether diabetes is a risk factor for hospitalisation with pneumonia and to assess the impact of HbA1c level on such risk.
Methods: In this population-based case-control study we identified patients with a first-time pneumonia-related hospitalisation between 1997 and 2005, using healthcare databases in Northern Denmark. For each case, ten sex- and age-matched population controls were selected from Denmark's Civil Registration System. We used conditional logistic regression to compute odds ratios (ORs) as a measure of relative risk (RR) for pneumonia-related hospitalisation among persons with and without diabetes, controlling for comorbidity, alcoholism-related conditions, pre-admission use of antibiotics and immunosuppressants, marital status, presence of small children in the household, and degree of urbanisation.
Results: The study included 34,239 patients with a pneumonia-related hospitalisation and 342,390 population controls. The adjusted RR for pneumonia-related hospitalisation among persons with diabetes was 1.26 (95% confidence interval (CI) 1.211.31) compared with nondiabetic individuals. The adjusted RR was 4.43 (95% CI 3.405.77) for patients with Type 1 diabetes and 1.23 (95% CI 1.191.28) for patients with Type 2 diabetes. Diabetes duration 10 years increased the risk of a pneumonia-related hospitalisation (adjusted RR 1.37; 95% CI 1.281.47). Compared with persons without diabetes, the adjusted RR was 1.22 (95% CI 1.141.30) for diabetic persons whose HbA1c level was <7%, and 1.60 (95% CI 1.441.76) for diabetic persons whose HbA1c level was 9.
Conclusions: Type 1 diabetes, and to some extent Type 2 diabetes, are risk factors for a pneumonia-related hospitalisation. Poor long-term glycemic control among patients with diabetes clearly increases the risk of hospitalisation with pneumonia.
|Session name:||18th European Congress of Clinical Microbiology and Infectious Diseases|
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