Diabetes, glycaemic control and risk of hospitalisation with pneumonia: a population-based case-control study

Abstract number: P835

Kornum J.B., Thomsen R.W., Riis A., Lervang H., Schønheyder H.C., Sørensen H.T.

Objective: To examine whether diabetes is a risk factor for hospitalisation with pneumonia and to assess the impact of HbA1c level on such risk.

Methods: In this population-based case-control study we identified patients with a first-time pneumonia-related hospitalisation between 1997 and 2005, using healthcare databases in Northern Denmark. For each case, ten sex- and age-matched population controls were selected from Denmark's Civil Registration System. We used conditional logistic regression to compute odds ratios (ORs) as a measure of relative risk (RR) for pneumonia-related hospitalisation among persons with and without diabetes, controlling for comorbidity, alcoholism-related conditions, pre-admission use of antibiotics and immunosuppressants, marital status, presence of small children in the household, and degree of urbanisation.

Results: The study included 34,239 patients with a pneumonia-related hospitalisation and 342,390 population controls. The adjusted RR for pneumonia-related hospitalisation among persons with diabetes was 1.26 (95% confidence interval (CI) 1.21–1.31) compared with nondiabetic individuals. The adjusted RR was 4.43 (95% CI 3.40–5.77) for patients with Type 1 diabetes and 1.23 (95% CI 1.19–1.28) for patients with Type 2 diabetes. Diabetes duration geqslant R: gt-or-equal, slanted10 years increased the risk of a pneumonia-related hospitalisation (adjusted RR 1.37; 95% CI 1.28–1.47). Compared with persons without diabetes, the adjusted RR was 1.22 (95% CI 1.14–1.30) for diabetic persons whose HbA1c level was <7%, and 1.60 (95% CI 1.44–1.76) for diabetic persons whose HbA1c level was geqslant R: gt-or-equal, slanted9.

Conclusions: Type 1 diabetes, and to some extent Type 2 diabetes, are risk factors for a pneumonia-related hospitalisation. Poor long-term glycemic control among patients with diabetes clearly increases the risk of hospitalisation with pneumonia.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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