Inhaled corticosteroids increase the risk of pneumonia? A further step in a population-based study

Abstract number: P833

Almirall J., Bolibar I., Serra-Prat M., Roig J., Hospital I., Carandell E., Agustí M., Ayuso P., Balanzó X., Torres A.

Aim of the study: To identify if the inhaled treatment general and inhaled corticoids in particular are risk factor for community-acquired pneumonia (CAP).

Patients and Methods: This was a population-based case-control study with a target population of 859,033 inhabitants >14 years of age. All patients with confirmed radiographic CAP presented over 1-year were prospectively registered (n = 3336). Each case of confirmed CAP was frequency matched to a control subject (n = 3326). Then we selected all chronic bronchitis or asthma diagnosis (CAP patients= 473 and controls=235) in order to compare the inhaler treatments. Then we adjusted for illness severity considering the use of oxygen therapy.

Results: Multivariable analysis including health habits, household and work circumstances, clinical conditions and comorbidities, and oral treatments, confirmed IT as independent risk factor of CAP. Among chronic bronchitis or asthma patients, IT remained a significant risk factor of CAP with a dose-related relationship, particularly when steroids or plastic pear-spacers were used (see table).

Conclusion: IT is a significant and independent risk factor of CAP in the general population and among patients with chronic bronchitis or asthma, particularly when medication contained steroids or plastic pear-spacers were used.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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