Risk factors for nosocomial Acinetobacter bacteraemia: a case-control study of intensive care unit patients

Abstract number: P794

Tunger O., Keles G., Cetin C.B., Gazi H., Coban S., Aras I., Sakarya M.

Objectives: This study was performed to identify risk factors and to determine the attributable mortality and outcome of Acinetobacter bacteraemia in intensive care unit.

Methods: A retrospective case-control (1:1) study was conducted in a tertiary, academic hospital, with 300 beds. From January 2001 to December 2006, 54 cases and 54 controls were included. Cases were all the true nosocomial bacteraemias by Acinetobacter spp. A control was defined as the consecutive patient with negative blood cultures, matched by sex, age (±10 years), primary and secondary diagnosis, APACHE II score (±2 points), operative procedures, and date of admission. Characteristics and mortality rates of patients with Acinetobacter bacteraemia and their controls were compared. The results were analysed using SPSS (version 11.0) for Windows.

Results: The mean age was 51.05±22.30 years (median = 56) for the cases, and 47.90±20.58 years (median = 44) for the controls. There was a trend for a longer median duration of hospitalisation among case patients, compared with control patients (33.31±30.67 versus 11.55±10.50 days; p = 0.06). Patients with Acinetobacter bacteraemia had significantly more hemodynamic instability (hypoxia, shock) and longer length of ventilator requirement than controls. Case-patients were more likely than controls to have had central venous catheter, peripheral arterial catheter, mechanical ventilation and total parenteral nutrition (p < 0.05). Thirty-three (61.1%) of the case patients died, compared with 14 (25.9%) of the control patients (p = 0.001). Attributable mortality is determined by subtracting the crude mortality rate of the controls from the crude mortality rate of the cases. The attributable mortality was 35.2%.

Conclusion: In critically ill patients Acinetobacter bacteraemia is associated with a significantly increased mortality rate.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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