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Can non-specific biochemical tests improve the diagnosis and contribute to prognosis in imported malaria?

Abstract number: P751

Poluga J., Stevanovic G., Pelemis M., Nikolic J., Pavlovic M.

Objectives: The objective of this study was to evaluate role of nonspecific biochemical tests in malaria diagnosis, according to their sensitivity, specificity and positive predictive values. In addition, comparison with parasitaemia, occurence of complications, recovery duration and organ failiure was examined to determine possible prognostic value of routine biochemical parameters.

Methods: A retrospective study included 64 patients, diagnosed and treated for malaria in Institute for Infectious and tropical diseases KCS, from January 1999. to December 2006. and healthy control group (n = 11).

Results: Thrombocytopenia, leukopenia, hyperglycaemia, hypocholesterolaemia and elevation of transaminases, lactate dehydrogenase (LDH) and creatinine were associated with malaria. Although thrombocytopenia had highest sensitivity (84%), hyperglycaemia, leukopenia and hyperbilirubinaemia were the most specific (100%) and with the strongest positive predicitive values (100%). Malaria complications were associated with anaemia, leukopenia, thrombocytopenia, hypoproteinaemia, hyponatraemia and elevation of LDH and creatinine. Hypocholesterolaemia, anaemia and fibrinogen elevation had a significant effect on recovery duration. Hepatosplenomegaly in malaria was associated with thrombocytopenia and LDH elevation, as jaundice was associated with anaemia.

Conclusion: Nonspecific laboratory test are useful for prompt and accessible orientation and avoidance of misdiagnosis in febrille travellers returning from endemic regions. Furthermore they proved as valuable auxiliary diagnostic and prognostic tools in combination with the microscopic detection of parasites.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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