Comparative activity of meropenem, imipenem and piperacillin / tazobactam against 1118 bacteria involved in hospital infections: a French multicentre study

Abstract number: P612

Joly-Guillou M.L., Cavallo J.D., Chomarat M., Dubreuil L., Maugein J., Muller-Serieys C., Roussel-Delvallez M., Soufflet C.

Objective: This study was designed to evaluate the activity of meropenem (MPM), against 1118 non repetitive strains isolated from bacteraemia (55%), pneumonia (29%), peritonitis (12%) and wounds infections (3%), during a survey carried out in 15 French community and university hospitals, in 2006. Susceptibility tests and Minimum Inhibitory Concentrations (MICs) of meropenem (MPM), imipenem (IPM) and piperacillin plus tazobactam (PTZ) were determined by Etest® method (ET) in each centre. Disc diffusion test for MPM and MICs by the agar dilution method (AD) for MPM, IPM and PTZ were determined in specific centres for E. coli (EC), others enterobacteriaceae (EB), Pseudomonas aeruginosa (PA), aerobic Gram-negative bacilli (AE), Acinetobacter (AB), meticillin susceptible Staphylococcus aureus (MSSA) and coagulase-negative staphylococci (MSCNS) Streptococcus pneumoniae (SP) and anaerobes (AN).

Results: MICs obtained by AD are listed in the table.

Conclusions: Compared to IPM, MPM displays lower MICs against EB, EC and PA. Except for AE, MICs90 of carbapenems are <4mg/l. Against AB, carbapenems display similar MICs; Compared to carbapenems, PTZ is less active against EB and AB but not PA. Some discrepancies were noted between MICs realised by ET in each centre and MICs realised by AD in specific centre. Especially for aerobics, MICs by ET were frequently higher than MICs by AD.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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