Comparison of the risk factors for Candida albicans versus other Candida spp. bloodstream infections in intensive care unit patients

Abstract number: O456

Timurkaynak F., Kurt Azap O., Serin Senger S., Cagir U., Arslan H.

Objectives:Candida species are the fourth leading aetiologic agent of bloodstream infections causing high morbidity and mortality rates. The aim of this study is to determine the risk factors for candidaemia including Candida albicans and non-albicans strains in intensive care unit patients.

Methods: Intensive care unit patients who had candidaemia between the period of January 2004 and October 2007 were included in this study. A structured form was used to collect data from the patient records about demographic characteristics, clinical and laboratory values and interventions for each patient. Chi-square test and logistic regression methods were used for statistical analysis.

Results: A hundred and two candidaemia patients were inluded in the study. Fifty-nine (57.8%) of the episodes were caused by C. albicans and 43 (42.2%) were caused by non-albicansCandida. The distribution of non-albicansCandida spp. were as follows; 12.7%Candida tropicalis, 8.8%Candida glabrata, 7.8%Candida famata and 12.9% other Candida spp. (Candida kefyr, Candida lusitaniae, Candida humicola, Candida parapsilosis, Candida spp.). There was no statistically significant difference in the distribution of Candida isolates between the years 2004 and 2007 (p > 0.05). The risk factor determined for C. albicans candidaemia was renal failure (acute or chronic) and risk factors for non-albicans candidaemia were solid organ transplantation and prior antifungal therapy. The statistical analysis regarding risk factors was summarised in the Table. There was no statistically significant difference between the rates of mortality among the two groups.

Conclusion:C. albicans is still the most common Candida species and there was no major difference in the distribution of the candidaemia isolates among our patients for the last three years. Renal failure was found to be the only risk factor associated with C. albicans candidaemia and prior antifungal therapy, either prohylactic or empirical, was found to be associated with non-albicans candidaemia. As it is well known that appropriate empirical antifungal therapy is the most important factor contributing to low morbidity and mortality rates, each centre should have their own surveillance data.

Table: Adjusted odds of covariates, associated with non-albicans candidaemia, multivariable analysis

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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