Fungiscope – the Global Rare Fungal Infection Registry

Abstract number: O453

Rueping M.J., Vehreschild J.J., Beisel C., Auerbach U., Mueller C., Wickenhauser C., Cornely O.

Introduction: The incidence of invasive fungal infections increases worldwide, and rare fungi – neither belonging to the genera Aspergillus, Candida, Pneumocystis or Cryptococcus, nor being endemic, such as Histoplasma spp. or Coccidioides spp. – are increasingly identified as causative pathogens.

Methods: We are coordinating a global registry for cases of rare invasive fungi. Our objective is to broaden the knowledge on epidemiology, to determine the clinical pattern of disease, to describe and improve diagnostic procedures and therapeutic regimens, as well as to facilitate exchange of clinical isolates among the contributors.

Entry of retrospective data occurs via a web-based registration system (MACRO) that focuses on demographic information, underlying diseases, risk factors, details on the infection (pathogen, localisation, specimen collection) therapy and outcome.

Inclusion criteria include cultural, histopathological, antigen, or DNA evidence of invasive fungal infection. Infection due to Aspergillus spp., Candida spp., Cryptococcus neoformans, Pneumocystis jirovecii or any endemic fungal infection, such as coccidioidomycosis or histoplasmosis, as well as mere colonisation or other non-invasive infection are exclusion criteria.

Each subset of this cohort will be published at a time. Authorship will be restricted to those centres, contributing patients or translational work to the subset.

For evaluable patient documentations filled in by the participating centre a compensation of [euro] 100 each will be paid. For isolates made available to the central laboratory an additional [euro] 50 will be paid.

Results: By now, 28 cases of rare invasive fungal infections have been identified, including Absidia corymbifera, Cunninghamella bertholletiae, Penicillium marneffei, Rhizomucor pusillus, as well as Acremonium spp., Fusarium spp., Coccidioides spp., and Trichoderma spp. Clinical results are partly pending. Most patients were in an immunocompromised state as a result of their underlying disease, chemotherapy or transplantation.

Discussion: The clinical relevance of invasive fungal infections by rare fungi is increasing steadily. In a short period of time, actual cases from Germany, Austria, Italy and the United Kingdom could be documented, showing the broad spectrum of pathogens.

Further investigators and coordinators are cordially invited to contribute to the success of Fungiscope.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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