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Seroprevalence of Chagas' disease in a general university hosiptal in Valencia, Spain

Abstract number: O406

Fraile Fariñas T., Martin Guerra S., Almiñana Martinez L., Tamarit Del Horno P., Gomez Muñoz N., Garcia Rodriguez M., Segarra Perez P., Parada Barba C.

Introduction: Chagas' disease is caused by infection with the protozoan agent Trypanosoma cruzi (T. cruzi).

Represents a serious blood safety problem due to increasing inmigration from Latin America. Outside of endemic areas, Chagas disease may be transmitted from the transfusion of infected blood components, congenital infections and organ transplantations.

The aim of this study is to determinate the seroprevalence of the T. cruzi antibodies in samples of people from endemic countries, people that travelling at these countries and sons from affected mothers born in Spain.

Methods: In 246 samples of 234 patients from 11 countries, we were tested by enzyme-linked inmunoassay (ELISA) (Dade Behring CHAG0560DB) for IgG antibodies against T. cruzi, and indirect inmunofluorescence (IFI) (Biocientífica SA Inmunofluor Chagas NF09–60) for IgG (Bio-Mérieux 75 692) and IgM (Bio-Mérieux 75 672) antibodies.

Results: The percentage of positive samples was 58 (23.58%)and their distribution as follows: 40 Bolivia's patients (69%), 2 from Ecuador (3.5%), 2 from Colombia (3.5%), 1 from Chile (1.75%) and 13 from Spain (22.25%).

Between the 13 Spanish's patients 7 of them were children (age between 0 and 6 years old); and the other 6 remaining patients were adult women.

These 6 women, fitting of endemic areas were obtained nationality in Spain.

We were detected IgM antibodies in 4 of the 7 children and also one child we were found a positive result by PCR.

Conclusion: The seroprevalence that we found in our considered samples was about 23.58% and the country with higher seroprevalence was Bolivia.

Many other countries showed relevant seroprevalence especially Latin-American countries; and that suppose migrations are a risk factor in destinations countries.

For this reason, Spain could be in a near future in Chagas's disease world distribution.

It's remarkable one case of vertical transmission with IgG and IgM antibodies and positive PCR. According to vertical transmission; children become a high risky population sector and this fact may be considered, not only about infected mothers.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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