Co-infection with zoonotic Campylobacter and Salmonella

Abstract number: O252

Gradel K.O., Kristensen B., Ejlertsen T., Schønheyder H.C., Nielsen H.

Objectives: We hypothesised that patients co-infected with thermophilic Campylobacter (TC) and non-typhoid Salmonella (NTS) had different characteristics than patients with TC or NTS mono-infections.

Methods: Population-based registry study comprising all TC/NTS co-infected patients (0–7 days between TC and NTS detection) and all first-time mono-infected TC or NTS patients in two Danish counties from 1991 through 2003. Data on recorded comorbidity were retrieved from the Danish Hospital Discharge Registry and data on one-year mortality from the Danish Civil Registration System.

Results: A number of 114 patients were co-infected and 13,335 had mono-infections (6,768 TC [50.8%] and 6,567 NTS [49.2%]). The age distribution (median [1st-3rd quartile]: 26.2 [19.2–44.4] years for co-infected vs. 29.7 [17.6–48.2] years for mono-infected), comorbidity (15 co-infected (13.2%) vs. 1,611 mono-infected [12.1%]; OR [95% CI] = 1.1 [0.6–1.9]), and seasonal distribution (peak date and peak-to-trough ratio [95% CI]: 22 August and 2.6 [1.4–4.9] for co-infected vs. 28 August and 4.4 [4.1–4.8] for mono-infected) did not differ between the two patient groups. All co-infected and 13,100 mono-infected patients (98.2%) were alive after one year (p = 0.15). Co-infected patients had a higher ratio of exotic NTS serotypes (in contrast to Salmonella Enteritidis and S. Typhimurium) than mono-infected NTS patients (53.5% vs. 21.8%; OR [95% CI] = 4.1 [2.8–6.1]), whilst there were no differences between S. Enteritidis and S. Typhimurium (OR [95% CI] = 1.1 [0.6–2.0]).

Conclusion: Co-infected patients were not frailer than mono-infected patients. The differences in serotype distribution amongst NTS infected patients indicate that infection sources and behavioural factors (e.g., travel) are more important determinants of co-infection vs. mono-infection than baseline patient characteristics.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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