Comparison of quality of life in inactive hepatitis B virus carriers versus chronic hepatitis B patients versus normal Turkish population
Abstract number: O184
Tasbakan M., Sertoz O., Pullukcu H., Calik S., Sipahi O., Yamazhan T.
Objective: It was aimed to evaluate the QOL in inactive HBsAg carriers with a control group who had a diagnosis of chronic hepatitis B and had not received any antiviral therapy, yet.
Methods: The study sample was consisted of two groups. First group was comprised of inactive HBsAg carriers recruited from individuals who were regularly followed-up in Infectious Diseases & Clinical Microbiology outpatient clinic of our setting due to inactive HBV infection [HBV DNA levels <103 copies/mL, Robogene Hepatitis B virus quantitation kit, Roboscreen, Germany) and normal biochemical parameters (Aspartat amino transferase-AST, alanine amino transferase-ALT, bilirubin, no HIV or HCV infection, no drug abuse.)]. Second group was recruited among patients who had a diagnosis of chronic HBV infection [Hepatic activity index 4 in liver biopsy, HBV DNA >20,000 IU/ml and AST, ALT 2× normal] and who were not undergoing active treatment yet. Both groups were requested to fill health related quality of life by means of short form 36 (HRQOL-SF-36) questionnaire and a form asking data of age, gender and education. The data of two groups were compared between each other and both groups were compared with QOL data of normal Turkish population.
Results: Of 131 inactive HBsAg carriers and 38 patients with chronic HBV diesease 128 (50 females, 78 males, mean age 41.4±12.3) and 28 (9 males, 19 females, mean age 36.68 ±10.56) accepted to be included in the study. The QOL data of group 1 and 2 are shown in Table 1. The groups did not show any significant difference by means of age and gender, though a significant difference was observed in educational level. HRQOL of patients showed a profile similar to that of the general Turkish population, with normal physical functioning, and vitality scores, but statistically significant lower role limitations due to emotional problems, bodily pain, general health perceptions, social functioning, role limitations due to physical health problems, and mental health domain scores (p < 0.001). HRQOL of patients with chronic HBV disease was also significantly lower in role limitations due to emotional problems, bodily pain, general health perceptions, social functioning, and role limitations due to emotional problems scores (p < 0.001).
Conclusion: QOL in inactive HBsAg carriers was quite similar to that of patients with chronic HBV disease and both inactive HBsAg carriers and patients with chronic disease had lower QOL than normal Turkish population.
Table 1: Comparison of quality of life between inactive HBsAg carriers and patients with chronic HBV infection and not undergoing active treatment
|Session name:||18th European Congress of Clinical Microbiology and Infectious Diseases|
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