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Oral side effects of antiretroviral therapy in HIV-infected patients

Abstract number: 1734_194

Nechifor M., Gradinaru I., Luca V.

Objective: To assess the incidence of oral side and adverse effects of some associations of antiretroviral chemotherapic drugs associations in HIV-infected patients (both children and adults).

Method: The study was performed on 72 children (age between 3 and 18), and 64 adults HIV-infected of both ganders, hospitalised in the Infectious Diseases Hospital ``Sf. Parascheva'' Ia°i between 2000 and 2005. All the included patients had CD4 lower than 400/mm3 and before hospitalisation had not received any other antiretroviral therapy. The study included only patients that were clinically surveyed over 90 days. Patients (both children and adults) received the following chemotherapeutic protocols: Zidovudine + Indinavir + Lamivudine (23 children and 18 adults); Efavirenz + Indinavir + Zalcitabine (29 children and 24 adults). Oral cavity was daily examined.

Results: Main side effects noticed were: erosions on gingival mucosa and inferior lip (6.2% of adults and 5.5% of children); ulceration of jugal mucosa (8.3% of adults and 3.1% of children), oral mucosa hyperpigmentation (3.1% of adults and 4.1% of children), xerostomia (11% of adults and 10% of children), necrotic stomatitis (2.7% of adults and 3.1% of children). In some patients there were more than one side effect. The presence of saburral tongue and oral candidosis was considered as disease complication (though it might be induced also by antiretroviral therapy). The incidence of oral side effects was about 27–28% in children and about 22–23% in adults. There were not observed in this study major difference regarding oral side effects between children and adults. Oral side effects observed did not impose discontinuation of antiretroviral therapy.

Conclusions: Oral side effects of antiretroviral therapy represent a certain fact which should be considered in the clinical practice.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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