Helicobacter pylori infection in symptomatic HIV-seropositive and seronegative patients: a case-control study
Abstract number: 1734_190
Panos G., Xirouchakis E., Tzias V., Charatsis G., Bliziotis I., Doulgeroglou V., Margetis N., Falagas M.
Objective: We conducted this study to evaluate the prevalence and morbidity of Helicobacter pylori infection in HIV seropositive patients.
Methods: Case-control study of HIV seropositive and seronegative patients in a tertiary care hospital in Greece.
Results: HIV seropositive patients were infected by H. pylori less often than HIV seronegative controls [12/58 (20.7%) versus 38/58 (65.5%), p < 0.001]. The mean CD4 count was lower for H. pylori negative than H. pylori positive HIV infected patients (p < 0.007). Also, among HIV patients, prior use of antibiotics or proton pump inhibitors was more common in those without H. pylori infection, a result that almost reached statistical significance (p = 0.06). The grading of the density of H. pylori infection and the grading of the histomorphological findings according to Sydney classification were similar between HIV seropositive and seronegative patients with H. pylori infection.
Conclusion: Our data suggest that HIV seropositive patients are infected by H. pylori less often than the general population. In addition, among patients with HIV infection, these with decreased CD4 cells are less likely to be co-infected with H. pylori.
|Session name:||European Society of Clinical Microbiology and Infectious Diseases|
|Location:||ICC, Munich, Germany|
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