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Mycological and pathological findings of sinus material from patients with chronic sinusitis

Abstract number: 1734_184

Can F., Demirbilek M., Ozluoglu L., Haberal N., Akkuzu B., Aydin E., Arslan H.

Background: Fungi are important aetiologic agents of sinusitis but incidence and fungal types have not been systematically studied. This study was designed to evaluate the incidence of fungi and dispersal of species in chronic sinusitis another aim of the study was to saw the correlation among microbiological and pathological findings.

Methods: Specimens of mucin, sinus secretions, and/or tissue were obtained intraoperatively from 60 cases of chronic sinusitis (without diabetes mellitus and/or immunosupression) and sent to the mycology and pathology laboratory. For microbiological findings; specimens were treated with Sputolysin and cultured on Sabouraud's dextrose agar, Mycosel agar, and Brain-Heart Infusion agar plates; and incubated at 30°C (and 37°C) for up to 6 weeks. Identifications were made according to standard procedures. For pathological findings; conventional H&E and Gomorie's methamine silver (GMS) stain were employed in all cases.

Results: The fungal species were demonstrated in 21 of 60 specimens. Aspergillus spp. was the commonest isolate (48%) and it was followed by dematiaceous fungi which found in 7 patients. Candida albicans were isolated from 2 patients and Curvularia lunata, Paecilomyces lilacinus, Chrysosporium spp. were isolated from one patient each.

Although allergic fungal sinusitis was detected in 17 of 21 patients (81%) that fungi were isolated by culture, it was found to be 51% (20 of 39) in fungal culture negative patients in histopathological examination (p < 0.5). According to the histopathological findings one patient had chronic invasive fungal sinusitis and Chrysosporium spp. was isolated from that patient.

Conclusion: Our data showed that allergic sinusitis was the most common part of chronic sinusitis (37 of 60) and fungi was isolated from 46% of them. Aspergillus spp. and dematiaceous fungi are most relevant species. These data would be important for clinicians while choosing the empiric drug therapies for chronic sinusitis.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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