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Elimination of Staphylococcus aureus nasal carriage in healthcare workers of a burn centre: effect on incidence of S. aureus of burn wound colonisation

Abstract number: 1734_141

Kooistra-Smid A.M.D., Nieuwenhuis M.K., Zanten van E., Hiddingh J., Beerthuizen G.I.J.M., Vogels W.H.M., Belkum van A., Verbrugh H.A.

Objectives:Staphylococcus aureus colonisation and infection of burn wounds increases morbidity and delays wound healing. S. aureus burn wound colonisation may result from nasal and pharyngeal colonisation of patients as well as healthcare workers (HCW). The aim of this study was to evaluate the effect of eradication of nasal S. aureus in HCW with mupirocin on the incidence of S. aureus burn wound colonisation.

Methods: HCW nasal S. aureus was eradicated with one course of mupirocin in July 2004. From July 2003 to June 2006 patients were extensively screened on admission for S. aureus carriage and burn wounds were cultured weekly. S. aureus burn wound colonisation during the year following mupirocin treatment (July 2004 to July 2005, n = 72) was compared with two control periods, C1 (July 2003 to June 2004, n = 54) and C2 (August 2005 to June 2006, n = 57).

Results: Forty-three (93%) HCW have received the mupirocin course. Nasal eradication was proven successful in 13/15 (87%) of the nasal carriers. HCW nasal carriage rate dropped from 35% to 2%, and gradually increased from 12% after 6 months to 25% after one year. The incidence of burn wound colonisation during admission in the year after the mupirocin course was 27/56 (48%) and for control groups C1 and C2 12/42 (29%) and 14/44 (32%) respectively.

Conclusion: Eradication of S. aureus nasal carriage among healthcare workers did not reduce S. aureus burn wound colonisation.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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