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Occurrence of Mycoplasma hominis in amniotic fluid of pregnant women

Abstract number: 1734_139

Vydrzalova M., Lyskova P., Mazurova J.

Background: Intrauterine infection is a major cause of preterm delivery, perinatal morbidity and mortality of fetus. Intrauterine infection is present in approximately 25% of all preterm births. The most common microorganisms involved in intrauterine infections are Ureaplasma urealyticum and Mycoplasma hominis. M. hominis is commonly isolated microorganism from the female genital tract. This microorganism can be found in 21% to 53% of sexually active women. The transmition from the mother to the developing fetus can happen in uterus during the pregnancy or during the delivery.

The relationship between detection of Mycoplasma hominis in mid-trimester amniotic fluid and subsequent pregnancy outcome was investigated. Data collected included indication for amniocentesis, gestational age at amniocentesis, gestational age at delivery, pregnancy outcome and low birth weight of infants.

Method: The amniotic fluids of 184 women who underwent a transabdominal amniocentesis at weeks 15–22 of pregnancy were tested for M. hominis by cultivation method on PPLO agar and broth with arginine. The isolates of M. hominis were confirmed by polymerase chain reaction.

Results:M. hominis were identified in 20 (11%) samples of the amniotic fluid. A total 8 infants had the birth weight below 2500g. Two of them were born to mothers whose amniotic fluid was positive for M. hominis. Nine of the women delivered preterm and one of them was positive for M. hominis.

Conclusion: The aim of this study was to investigate the occurrence of M. hominis in amniotic fluid of pregnant women. The presence of M. hominis in amniotic fluid could be associated with low birth weight of infants which was confirmed by other authors. This work was supported by MSM 0021627502

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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