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Study of urinary tract infection in diabetic and non-diabetic patients and antibiotic sensitivity pattern of isolated organisms

Abstract number: 1734_135

Alimohammadi asl H., Fouladi N.

Objectives: The main objective of this study was to determine whether there are any differences in the bacteriological pattern of UTI and the antibiotic sensitivity patterns of the pathogens concerned between diabetic and nondiabetic patients.

Methods: Over a period of one year, a total of 1510 patients suspected to have urinary tract infections (UTI) were studied.

Results: of the test patients 452 of them were diabetics. 102 (22.5%) of 452 diabetic patients had UTIs from which 72 patients (70.5%) were female. In non diabetic group (control group) 120 patients were selected out of 1058 non diabetic patients as having UTI. Regarding age and sex of the patients on diabetic and nondiabetic patients meaningful statistical difference, were found. the infections in both groups were further divided into community acquired and nosocomial acquired UTI in non diabetic patients (73.3%), this organism was isolated in 43.6% of the community acquired UTI in diabetic patients and this finding indicates a meaningful statistical difference in two groups.

The organisms isolated from nosocomial UTI in diabetics showed a significantly greater preponderance of klebsiella spp. (41%) as compared to non diabetics (29%) which statistically is a meaningful difference.

Most of the UTI in diabetics, especially in female, were asymptomatic. In 31 E. coli strains isolated from diabetic and non diabetic patients type 1 fimberia also investigated, which in diabetic patients 43.7% of the isolated strains showed this type of filmberia as compared to E. coli strains isolated from non diabetic patients (73.3%) indicating a meaningful difference.

Antibiotic sensitivity patterns of the isolated strains were determined using some of the routine antibiotics used in UTI treatment, some of third generation cephalosporins and quinolones, but the results showed no statistical differences. Although when WBC conuts in 1mm3 of the infected test urines were compared in diabetic and nondiabetic patients, the sensitivity of the test recorded as 58.3% and 92%, respectively, but the sensitivity of nitrate reduction test in the both groups was not statistically significant.

Conclusions: Most of the UTI in diabetics, especially in female, were asymptomatic. sensitivity and bacteriological patterns between diabetic patients and control group were different. Routine urine culture can be recommended for diabetic women even when there is no urinary symptom.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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