Surgical antibiotic prophylaxis in a Turkish university hospital

Abstract number: 1733_1600

Serin Senger S., Togan T., Kurt Azap O., Timurkaynak F., Arslan H.

Objective: Since surgical site infections are important causes of morbidity, mortality, and healthcare costs, we aimed to assess the appropriateness of use of surgical antimicrobial prophylaxis at our institution.

Methods: A retrospective evaluation of the use of antimicrobial prophylaxis in patients undergoing major surgery at Ba[scedil]kent University Hospital from July to September 2006 was carried out. The surgical operations included were liver and kidney transplantations, cardiovascular surgery, urological operations, neurosurgical operations, head and neck surgeries, orthopaedic surgery, breast surgery, general abdominal colorectal surgery, and abdominal and vaginal hysterectomy. Patients having infectious diseases prior to the surgery were excluded. The guidelines to assess choice of antimicrobial agent and duration of prophylaxis, were ASHP Therapeutic Guidelines on Antimicrobial Prophylaxis in Surgery (1999), IDSA (Antimicrobial Prophylaxis for Surgery: An Advisory Statement from the National Surgical Infection Prevention Project) (2004), and Sanford Guide (2005).

Results: A total of 148 patients with a mean age of 41.9 years (ranged 1–89 with SD = 24.5) were included in the study. General Surgery was the leading department where 50 (33.8%) of the operations were performed. Cefazolin was the most commonly used antibiotic (constituting 48.0% of all the antimicrobial agents) during the study period. In 77 (52.0%) of the cases the prophylaxis decisions were appropriate, with proper choices of antibiotics in 51 cases and omissions in 26, in accordance with the guidelines. Unnecessary prolongation of prophylaxis in the patients of appropriately chosen antibiotics was found to be 41.0%.

Conclusion: The results showed a significantly high level of inappropriate use of antimicrobial prophylaxis in our institution. To improve the proper use of prophylactic antimicrobials, the infection control committee planned to prepare a local guideline and to organise educational sessions for the surgeons.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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