Three-year study of hepatitis A, B and C infection prevalence in a major Greek hospital

Abstract number: 1733_1383

Karabassi V., Poujioyka M., Petrochilou K., Achilleos C., Dimitriou V., Toutouza M.

Objectives: The purpose of this study was to perform a serological analysis of Hepatitis A, B and C virus (HAV, HBV and HCV) infection prevalence in the patients of a Greek major hospital within a three-year period.

Methods: During the three last years 1/7/2003–30/6/2006, sera from 15,790 patients (13,090 in-patients and 2,700 out-patients), were tested for the detection of HAV, HBV and HCV markers. There were 4 groups of patients: Group A, 5,065 patients (3,745 in-patients, 1,320 out-patients) who were controlled for HBV surface antigen (HBsAg); Group B, 10,725 patients (9,345 in-patients and 1,380 out-patients) who were controlled for the HBV markers HBsAg, HBeAg, antiHBe, antiHBcore, antiHBs; Group C, 11,160 patients (9,600 in-patients, 1,560 out-patients) who were controlled at the same time for HCV-antibodies (HCVAb); and Group D, 1,610 patients (1,230 in-patients, 380 out-patients) who were controlled for HAV-antibodies (HAVAb, total and IgM). All tests were performed during 2003–2004 by MEIA methodology (AXSYM – ABBOTT) and during 2005–2006 by immunoluminometric assay method (ARCHITECT – ABBOTT).

Results: In Group A, of the 3,745 in-patients and 1,320 out-patients, 75 (2%) and 41 (3.1%). respectively, were found to be positive for HBsAg. In Group B, of the 9,345 in-patients and 1,380 out-patients there were, respectively, 4364 (46.7%) and 610 (44.2%) seronegative for HBV markers, 607 (6.5%) and 173 (12,5%) positive for HBsAg, 1,476 (15.8%), 87 (6.3%) positive for antiHBs due to HBV vaccination, 2,897 (31%) and 510 (37%) negative for HBsAg and positive for the rest HBV markers. In Group C, of the 9,600 in-patients and 1,560 out-patients, HCVAb-positivity was found in 221 (2.3%) and 94 (6%), respectively. 2% of them were at the same time positive for HBsAg. In Group D, of the 1,230 in-patients and 380 out-patients HAVAb total positivity was found in 652 (53%) and 194 (51%) and HAVAb IgM positivity was found in 25 (2%) and 5 (1.3%) respectively.

Conclusions: This study showed that there is a significant prevalence of HAV, HBV and HCV infection in the patients of our hospital (53%, 37.5%, 2.3% for in-patients; 51%, 49.5%, 6% for out-patients, respectively). The effort for the prevention must be continual and the control measures with the systematic Hepatitis A and Hepatitis B vaccination should be strictly enforced.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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