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Present situation of antimicrobial resistance of Staphylococcus in Spain: Sixth Nationwide Prevalence Study and the in vitro activity of new antimicrobial agents

Abstract number: 1733_1320

Cuevas O., Cercenado E., Goyanes M., Marin M., Vindel A., Bouza E.

Objective: Data regarding the evolution of Staphylococcus resistance in a whole country have a definite influence in the design of empirical treatment regimens. For the last 20 years we have been performing prevalence studies in order to ascertain the situation of the antimicrobial resistance of Staphylococcus in our country. In this study we present the results of the sixth point prevalence study performed in 2006.

Methods: In a selected day of October 2006, we collected all staphylococci isolated in 145 Spanish hospitals. All microorganisms were sent to a reference laboratory where identification and antimicrobial susceptibility testing was performed against 15 antimicrobial agents using and automated microdilution method (MicroScan). Additional E-test susceptibility testing was performed for the new antimicrobials daptomycin and tigecycline. We present the data of 75 hospitals, and 260/223 S. aureus/coagulase negative staphylococci (CoNS) isolates analysed to date and compare the results with these of the fifth study performed in 2002.

Results: The percentages of resistance of S. aureus/CoNS against selected antimicrobials (PEN=penicilin, OXA=oxacillin, ERY=erythromycin, CLI=clindamycin, GEN = gentamicin, TOB = tobramycin, CIP = ciprofloxacin, RIF = rifampin, T/S = trimethoprim/sulfamethoxazole, VAN = vancomycin), are summarised in the table. Resistance to linezolid, daptomycin, and vancomycin was found among CoNS (one isolate each). All strains were susceptible to tigecycline. The most frequent phenotypes of resistance among methicillin-resistant S. aureus were: ERY+CIP+TOB (75%); ERY+CIP+TOB+CLI (11%); ERY+CIP+TOB+CLI+GEN (14%). Fenotype M was present in 40% of isolates.

Percentage of resistance of S. aureus/CoNS to selected antimicrobials

YearResistance (%), S. aureus/CoNS
PENOXAERYCLIGENTOBCIPRIFT/SVAN  
200288/7931/6333/6420/3518/35ND/ND37/502/72/220/0
200688/9028/7032/6518/4410/4326/5037/531/60/300/0.5

Conclusions: The resistance of S. aureus to methicillin in Spain seems to be stabilised (28% in 2006 versus 31% in 2002), and strains are more susceptible to other antimicrobials, mainly to gentamicin and clindamycin. However, resistance of CoNS to all antimicrobials is increasing and emerging resistance to the new antimicrobial agents has been detected

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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