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Comparison of the effects of erdosteine and n-acetylcysteine on the levels of glutathione, myeloperoxidase, plasma and tissue malondialdehyde in experimental sepsis model

Abstract number: 1733_1287

Ayan M., Gül M., Seydanoglu A., Erayman I., Erdem S., Cander B.

Objective: The aim of this study was to determine the effects of N-Acetylcysteine (NAC) and Erdosteine as antioxidant agents on the free radicals and their plasma levels.

Methods: Fourty Sprague-Dawley rats were randomly divided into four groups. Group I was the control group. Group II received no treatment. Group III and group IV received orally NAC (20 mg/kg/24 h) and Erdosteine (20 mg/kg/24 h) after Cecal Ligation and Perforation (CLP) respectively. White blood cell (WBC) count, erythrocyte glutathione (GSH), leucocyte myeloperoxidase (MPO) and plasma malondialdehyde (MDA) were assessed in all groups.

Results: In groups III; WBC, erythrocyte GSH, and plasma MDA levels were measured higher than control group (p < 0.05). However, in groups IV; WBC, erythrocyte GSH, and plasma MDA levels were measured higher than control group, but not statistically significant (p > 0.05). The lung tissue MDA levels decreased in group III and IV according to control group (p < 0.05).

Conclusion: By the administration of NAC and Erdosteine as antioxidant agents al lower doses many meaningful positive effects were detected on the levels of WBC, erythrocyte GSH, and plasma MDA. These findings suggest that NAC and Erdosteine could be a possible therapeutic agent for sepsis and its mortality. However, further studies are needed to elucidate the effects of these drugs at higher doses.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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