Dose-dependent effects of octreotide on oxidant-antioxidant imbalance during experimental sepsis in rat

Abstract number: 1733_1286

Seydanoglu A., Gül M., Ayan M., Erayman I., Toy H., Girisgin S.

Objective: Sepsis remains one of the leading causes of death in intensive care units, despite recent acquired knowledge on pathophysiology and treatment. Oxidant-antioxidant balance involves different pathways and yet, there is no ideal drug able to affect all of them. The aim of this study was to investigate whether Octreotide (OCT), a synthetic somatostatin analogue, has antioxidative effects in experimental sepsis.

Methods: Fourty Sprague-Dawley rats were randomly divided into four groups. Group I was the control group. Group II received no treatment. Group III and group IV received subcutanously (sc) OCT 50 mg/kg and 100 mg/kg after Cecal Ligation and Perforation (CLP) respectively. White blood cell (WBC) count, erythrocyte glutathione (GSH), leucocyte myeloperoxidase (MPO) and plasma malondialdehyde (MDA) were assessed in all groups.

Results: In group sepsis, while MDA increased in sepsis periods, GSH decreased when compared with group Sham (p < 0.05). Increase in MDA levels and decrease in GSH levels after CLP-induced sepsis was significantly prevented by OCT 100 mg/kg sc administration (p < 0.05).

Conclusion: Octreotide seems to have a dose-dependent antioxidative effect in CLP-induced sepsis in rats. As a drug with the wide magrin of safety and less adverse reaction profile merits consideration as a choice of treatment in sepsis and septic shock.