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The effects of probiotics on allergy

Abstract number: 1733_1267

Can R., Aridogan B., Demirci M.

In this study, we aimed to investigate the effects of the probiotic mixture which we prepared from Lactobacillus and Enterococcus strains isolated from healthy human gut flora and the standard Lactobacillus GG (ATCC 53103) probiotic strain on immune responses in allergy in an experimental animal model.

We prepared a mixture from a total of 13 probiotic strains composed of 10 Lactobacilli (8 Lactobacillus plantarum, 2 Lactobacillus rhamnosus) and 3 Enterococcus faecalis which are isolated from the gut flora of healthy people. We administered the probiotic mixture, standard strain LGG and skim milk suspension orally to Balb-c mice in the study and control groups for 28 days. The mice in the study groups were immunised by intraperitoneal injection of Ovalbumin on days 14 and 21 and the mice in the control groups were injected PBS only.

The OVA specific IgE levels were assayed by ELISA method in serum in each group. The OVA specific IgE levels of the study groups which were administered probiotic and standard strain were found lower than the skim milk fed groups. The difference was statistically significant (p < 0.001).

The OVA specific IgE levels in the group which was given the probiotic mixture were found lower than the group which was fed by a standard probiotic diet but the difference was insignificant. There was statistically no difference between the OVA specific IgE levels of the control groups which were not immunised (p > 0.05). The OVA specific IgE levels of the study groups were found significantly higher than the control groups (p < 0.001).

OVA-specific IgE levels in study and control group.

In conclusion, probiotics may put forward to treatment of allergic diseases as a new alternative but specific strains of probiotics with immunoregulatory effects need to be clearly identified and their mechanisms of action will have to be well characterised.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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