Mycobacterium mucogenicum pulmonary infection in an immunocompromised patient

Abstract number: 1733_1118

Gitti Z., Neonakis I., Stylianoudaki E., Papadopoulou E., Maraki S., Spandidos D.

Background: Infections caused by non-tuberculous mycobacteria are continuously increasing. Mycobacterium mucogenicum is a recently characterised, rapidly-growing mycobacteria, rarely seen in human infections. Here we report the clinical and laboratory findings of a M. mucogenicum pulmonary infection in an immunocompromised patient.

Case presentation: The patient was a 70-year-old male with non-Hodgkin's lymphoma. He was admitted with a low-grade fever of 37.7° C and dyspnea of two months duration. Clinical examination revealed pulmonary involvement. A chest X-ray showed pulmonary infiltrates, multiple nodular lesions, and perihilar adenopathy. Mantoux skin test was negative. His past medical history was significant for chronic obstructive pulmonary disease and arterial hypertension. Ziehl–Neelsen acid fast staining of the gastric fluid was positive. Liquid and solid cultures of the sample yielded mycobacteria. The identification of the isolate as M. mucogenicum was performed by Genotype AS diagnostic reverse hybridisation strip test assay (Hain Lifescience, Germany). Antimicrobial susceptibility was determined by the E-test. The isolate was sensitive to cefoxitin, imipenem, clarithromycin, azithromycin, doxycycline, linezolid, cotrimoxazole, ciprofloxacin, sparfloxacin, moxifloxacin, tobramycin. Combined therapy with clarithromycin and ciprofloxacin for 4 months was proved effective.

Conclusion: Non-tuberculous mycobacteria can cause considerable pulmonary infections in immunocompromised patients. M. mucogenicum is most frequently found in the environment but is also incriminated for human infections. Early diagnosis is important for the determination of the appropriate treatment.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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