Methicillin-resistant Staphylococcus aureus from the lower respiratory tract: a cause for concern?

Abstract number: 1733_1096

Wadula J., Vally S., Adams T., Khoosal M.

Background: Methicillin-resistant Staphylococcus aureus has emerged, as a significant cause of pneumonia and infection caused by this organism has been associated with high mortality.

Recent reports allude to the fact that Staphylococcus aureus strains carrying the Panton-Valentine Leukocidin gene are highly associated with lethal necrotising pneumonia in healthy individuals. Community-associated methicillin-resistant Staphylococcus aureus strains have been implicated specifically to harbour the Panton-Valentine Leukocidin gene.

Objectives: To substantiate Methicillin-resistant Staphylococcus aureus (MRSA) strains in relation to whether, they are community-associated or hospital-acquired as defined by molecular definition of specifically looking for the panton-valentine leukocidin gene.

To document the reported antimicrobial sensitivity patterns of MRSA strains.

Methods: Retrospective laboratory data collection of all MRSA cultured from good quality sputum and tracheal aspirates during a nine-month period commencing July 2005 through to March 2006. Majority of these MRSA cultures were from patients in intensive care unit.

Sixty-seven cultures of MRSA from July 2005 to March 2006 were evaluated to confirm the identification, establish the presence of mecA and PVL genes (Hain Lifescience, Germany).

Results: Sixty-four (97%) of the 66 strains harboured the MecA gene while none of the 66 carried the PVL gene.

These strains exhibited multiple antibiotic resistance in keeping with hospital-acquired MRSA strains.

Conclusion: There is a predominance of hospital-acquired MRSA strain in our hospital, which highlights the need to constantly adhere to infection control measures.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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