Myocarditis heart failure associated with Adenovirus infection
Abstract number: 1733_1048
Goyenechea A., Palerm L., González G., Kouri V., Martínez A., Sarmiento L., Rosario D., Guzmán M., Valdes O., Acosta B., Savon C., Piñón A.
Objective: Rapid detection of aetiological agent causing myocarditis using molecular tools.
Methods: During an atypical outbreak of acute febrile syndrome of viral aetiology, 8 children ranged between 5 months aged to 12 years old have died in cardiogenic shock due to myocarditis, on July and August, 2005, in Havana city, Cuba. Nested polymerase chain reaction (nPCR) was used to detect the genomic sequences of Enterovirus, Adenovirus, Cytomegalovirus (CMV), Herpes simplex virus (HSV), Epstein Barr virus (EBV), Varicella zoster virus (VZV), Human Herpes virus 6 (HHV6), Flavivirus, Alphavirus, human Respiratory syncytial virus (hRSV) and Influenza virus (A, B and C) in tissue samples (heart, lung, brain and tonsil), cerebrospinal fluid and faeces specimens.
Results: We found evidence for the Adenovirus genome in a significant proportion of patients, 6 (75%) of them. Non others viruses were detected. The predominant clinical picture was characterised by acute cardiac decompensation and progress to death. In these cases the organs most common detected were lung (83%) and myocardium (67%). In three cases adenovirus was detected in both organs. Electrocardiography changes suggestive of myocarditis were detected in all patients. Histopathology findings characterised by an infiltrate of inflammatory cells and myocardial necrosis, established the anatomapathologic diagnosis of myocarditis post-mortem.
Conclusion: After exclusion of other possible causes of death, our results indicate that viral myocardial affection is the cause of death in Adenovirus positive cases. It should be noted that this is the first report about the molecular diagnosis of Adenovirus in myocarditis cases in Cuba.
|Session name:||European Society of Clinical Microbiology and Infectious Diseases|
|Location:||ICC, Munich, Germany|
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