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The value of interleukin-6 as a predictor of tissue injury due to hepatitis B virus replication

Abstract number: 1733_994

Cojocaru M., Cojocaru I., Matei I., Iacob S., Ene G., Delagramatic M.

Objectives: Interleukin 6 (IL-6) is a critical mediator for various host responses. IL-6 also plays the principle roles in the induction of the hepatic acute phase responses. The purpose of the present study is to clarify (1) the relationship between the magnitude of tissue injury and the elevation of serum IL-6, and (2) the change in serum IL-6 and acute phase reactants.

Methods: Serum samples were obtained from 33 patients with chronic HBsAg positive hepatitis diagnosed by ultrasonography, liver biopsy and histopathology. Their ages ranged from 29 to 58 years with a mean of 46±5 years. Another 20 healthy, age and sex matched adults with no evidence of liver disease were also included as a control group. For all cases and controls, full history taking, thorough clinical examination and the following routine laboratory tests were done: Complete blood count; liver function tests including measurement of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, g-glutamyltransferase (GGT), total proteins, albumin and bilirubin serum. Hepatitis B surface antigen (HbsAg) and HCV antibody were detected in the sera of patients and control subjects by an enzyme linked immunosorbent assay (ELISA).

Results: Serum IL-6 was measured with an ELISA using a monoclonal antibody against IL-6. The normal range of serum IL-6 was less than 4 pg/mL, CRP less than 0.5 mg/dL. Serum IL-6 was elevated in 28 patients (1,400.8±383.4 pg/mL), and serum CRP was elevated in 30 patients (68±8 mg/dL). The elevation of serum IL-6 was significantly correlated with the elevation of serum CRP (r = 0.84).

Conclusion: Serum IL-6 is an informative and sensitive marker to show the extent of tissue injury due to hepatitis B virus (HBV) replication.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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