European Society of Clinical Microbiology and Infectious Diseases

Determination of caspofungin plasma concentrations in surgical intensive care unit patients

Abstract number: 1733_791

Nguyen H., Hoppe-Tichy T., Geiss H., Weigand M.

Objectives: The aim of the present study was to investigate plasma caspofungin concentrations in surgical intensive care unit [SICU] patients.

Methods: According to their demographic data (Table) caspofungin concentrations of ten adult subjects were compared in a pairwise manner. All patients received an initial caspofungin loading dose of 70 mg followed by 50 mg/day. Caspofungin trough concentrations [C24h] were determined daily for the duration of therapy using High-Performance-Liquid-Chromatography.

Results: Plasma caspofungin C24h differed significantly between paired subjects (Table). Importantly, on more than one day, caspofungin C24h for five patients were found to have fallen below the target concentration of 1 mg/mL (see data ranges on Table).

Pair	Age	BW (kg)/BS (m²)	Mean C_24 h (mg/mL) [range]	p-value
1 (F)	47 vs. 46	47/1.45 vs. 48/1.46	1.6 [0.91–2.45] vs. 3.48 [1.54–5.01]	0.028
2 (F)	41 vs. 40	72/1.89 vs. 75/1.82	1.04 [0.7–1.74] vs. 2.22 [2.08–2.36]	0.068
3 (M)	72 vs. 65	75/1.93 vs. 75/1.92	1.24 [0.85–1.62] vs. 2.43 [1.97–2.77]	0.028
4 (M)	60 vs. 69	80/1.98 vs. 80/1.65	0.93 [0.55–1.47] vs. 2.0 [1.68–5.1]	0.043
5 (M)	54 vs. 56	77/19.5 vs. 70/1.76	1.34 [0.74–1.97] vs. 3.0 [1.63–3.63]	0.005
^aF, female; M, male. ^bBW, body weight; BS, body surface.

Conclusion: Our data indicate the importance of C24h monitoring in SICU patients. Further investigations are needed to evaluate the parameters which influence plasma caspofungin concentrations in this patient group.

Session Details

Date:	31/03/2007
Time:	00:00-00:00
Session name:	European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location:	ICC, Munich, Germany
Presentation type:
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