Determination of caspofungin plasma concentrations in surgical intensive care unit patients
Abstract number: 1733_791
Nguyen H., Hoppe-Tichy T., Geiss H., Weigand M.
Objectives: The aim of the present study was to investigate plasma caspofungin concentrations in surgical intensive care unit [SICU] patients.
Methods: According to their demographic data (Table) caspofungin concentrations of ten adult subjects were compared in a pairwise manner. All patients received an initial caspofungin loading dose of 70 mg followed by 50 mg/day. Caspofungin trough concentrations [C24h] were determined daily for the duration of therapy using High-Performance-Liquid-Chromatography.
Results: Plasma caspofungin C24h differed significantly between paired subjects (Table). Importantly, on more than one day, caspofungin C24h for five patients were found to have fallen below the target concentration of 1 mg/mL (see data ranges on Table).
Conclusion: Our data indicate the importance of C24h monitoring in SICU patients. Further investigations are needed to evaluate the parameters which influence plasma caspofungin concentrations in this patient group.
|Session name:||European Society of Clinical Microbiology and Infectious Diseases|
|Location:||ICC, Munich, Germany|
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