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Candida kefyr: a new emerging pathogen?

Abstract number: 1733_786

Agudo S., Navarro J., De Las Cuevas C., Moreno M., Buendia B., Domingo D., Alarcon T., Lopez Brea M.

Introduction:Candida species are present as normal microflora in humans, alterations in host defences can lead to the development of the disease. Candida infections include a wide range of infections, they are common in immunodepressed patients. Infections with non-albicansCandida species are becoming more frequent. Candida kefyr is an uncommon fungal pathogen. It is found in dairy products and in humans as normal flora of the respiratory tract, but it is rare in the skin. This organism has been isolated from multiple milk products, for example bovine milk contains at least 16 different species of yeasts including C. kefyr. In this study we report 6 cases of C. kefyr isolation.

Methods: All the specimens received at the Department of Microbiology (Hospital Universitario de la Princesa, Madrid) from January 1st 2004 to November 8th 2006 were cultured according to standard microbiological procedures. Yeast identification was performed using ChromAgar®, morphology in Corn Meal Agar and Auxacolor®. Clinical files of C. kefyr positive patients were checked.

Results: 6 cases of C. kefyr isolation were found, 5 of which were obtained in the last year. It was only a 0.1% incidence rate of all Candida species isolated during these three years. Case 1 was a 82 year-old woman who had multiorganic failure in the context of respiratory failure after pulmonary thromboembolism. Case 2 was a 91 year-old woman who suffered a stroke with important neurological consequences. Case 3 was a 83 year-old who had several repetitions of urinary tract infections. In the first and the second cases, C. kefyr was isolated from urine cultures in May 2006. In the third case, it was found in urine culture in January 2005. Case 4 was a 73 year-old man with multiorganic failure caused by hepatic encephalopathy. This case of C. kefyr was detected in bloodstream in September 2006. Case 5 was a 77 year-old man with acute renal failure and respiratory failure; C. kefyr was found in bronchoaspirate in April 2006. Case 6 was a 87 year-old woman with gastric cancer; C. kefyr was isolated from peritoneal liquid in October 2006.

Conclusion:C. kefyr is an uncommon human pathogen. The three patients reported here were elderly and had severe physical deterioration; however the clinical significance of these isolates remains unclear. C. kefyr infections reflect the increase in Candida species as responsible of disseminated infections in immunodepressed patients.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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