Host susceptibility to accute community-acquired bacterial meningitis: multicentre study of genetic markers

Abstract number: 1733_756

García-Cabrera E., Amaya-Villar R., Barroso S., Sulleiro E., Rodriguez D., Fernández-Viladrich P., Coloma A., Catalan P., Rodrigo C., Fontanals D., Grill F., Juliá M.L., Vázquez J.A., Pachon J., Prats G.

Objective: The aim of this study was to investigate the influence of host genetic factors in the susceptibility and clinical outcome in patients with acute community-acquired bacterial meningitis (ACABM).

Methods: An observational, prospective, and multicentre study carried out in 9 hospitals of the Spanish Network for the Research in Infectious Diseases, between the 1/11/2003 and 30/09/05. A total of 102 Spanish Caucasian patients (paediatrics and adults) with ACABM and 135 healthy controls (blood donors) from the same ethnical origin were included in the study. The following polymorphisms were genotyped using PCR-ARMS or PCR-RFLP: promoter and allelic variants of mannose-binding lectin gene and GC polymorphism of complement component C7 gene. At admission to the hospital, we studied the presence of the following predicting variables of unfavourable evolution (Ann Inter Med 1998; 129: 862–869): hypotension, altered mental status, and/or seizures. Unfavourable outcome was considered in the presence of neurological and/or auditory sequels to the hospital discharge and hospital mortality.

Results: Altered mental status was more frequent in patients homozygous for the C allele of C7 than for the other genotypes (76.7% vs 49%, respectively; p = 0.014). Patients homozygous for the G allele developed more neurological sequels or auditive deficits at the hospital discharge than the rest of genotypes (41% vs 16.4%; p = 0.0287). No association was found between C7 polymorphism and intrahospitalary mortality (p = 0.841).

Conclusions: Our results show that the presence of genotype CC for polymorphism GC of C7 is associated significantly with alteration of the level of consciousness at admission to the hospital and developing of neurological or auditive deficit in patients with acute community-acquired bacterial meningitis, although we have found no association with increased mortality.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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