Outbreaks of invasive meningococcal disease caused by Neisseria meningitidis group C in two regions of southern Poland

Abstract number: 1733_753

Pisula A., Janczewska-Kazek E., Szczerba-Sachs A., Posmyk U., Kosciow K.

Neisseria meningitidis (Nm) is still an important cause of life-threatening infections. Infections with group B strains are the most common in Poland, but infections with group C strain are rare.

Between June and November 2006 in two neighbouring regions, Silesia and Opole, 13 cases of invasive meningococcal disease (IMD) caused by Nm group C were noted. First cases were observed in Silesia region in 3 teenagers (all 16 years old, 1 male, 2 females) and 25-year old woman who meet together in the same discotheque. The IMD form in one woman and the man from this group was meningitis, but in 2 women it was sepsis with disseminated intravascular coagulation (DIC). The epidemiological investigation has shown the connection between sharing of glasses or intranasal inhalations of illegal drugs and IMD development in this group. Prevalence of Neisseria meningitidis group C carriage in nasopharyngeal cavity among habitual guests of the discotheque was 24%. One discotheque worker was also a Nm carrier.

The next cases were noted among 3 children (5, 10 and 2 years old) from families living in the same house in poor household condition. Nobody from their environment was Nm carrier.

In Opole region 4 cases of meningitis (3 men and 1 woman) and 2 cases of sepsis with disseminated intravascular coagulation (1 man, 1 woman) were noted in patients aged 16–57. One case of sepsis and one case of meningitis caused by C ST11 strain resulted in patients' death. The epidemiological investigation has shown no connections between these patients and their environments. In 2 persons from these patients families carriage of Nm group C was confirmed.

86 persons from environment received the chemoprophylaxis (ciprofloxacin, rifampicin). There were no new infections till half of November 2006.

Conclusions: (1) An important risk factor of invasive meningococcal disease is intranasal inhalation of illegal drugs using the same straw. (2) Vaccination against Neisseria meningitidis group C should be widely conducted in children and teenagers.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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