Endemic serogroup W135 meningococcal meningitis possibly originated from 2000 and 2001 Hajj epidemics: a prospective study for the aetiology of childhood acute bacterial meningitis in Turkey
Abstract number: 1733_712
Ceyhan M., Yildirim I., Balmer P., Borrow R., Secmeer G., Dikici B., Turgut M., Kurt N., Aydogan A., Ecevit C., Anlar Y., Gulumser O., Tanir G., Salman N., Gurler N., Aydin N., Hacimustafaoglu M., Celebi S., Coskun Y., Alhan E., Celik U., Camcioglu Y.
Determination of bacterial meningitis aetiology is important for decisions about vaccine policies. Cerebrospinal fluid (CSF) samples taken from patients with a clinical and laboratory diagnosis of acute bacterial meningitis were obtained from 12 health centres in 7 different geographical regions that provide health service to 32% of the population of Turkey. Streptococcus pneumoniae, Haemophilus influenzae type b (Hib) and Neisseria meningitidis were detected by PCR. During a period of one year, 408 CSF samples were included and bacterial meningitis was detected in 243 samples. N. meningitidis was detected in 56.5%, S. pneumoniae in 22.5% and Hib in 20.5% of PCR positive samples. Among N. meningitidis positive CSF samples, 42.7%, 31.1%, 2.2% and 0.7% belonged to serogroups W135, B, Y, and A, respectively. Serogroup W135 was the predominant serogroup in Turkey, except for the south coast and northwest of the country. This study showed a shift to serogroup W135 whereas serogroups A and B previously predominated. Vaccines to prevent meningococcal disease should include serogroup W135 in Turkey and possibly in other countries where many muslim pilgrims are travelling annually to the Hajj.
|Session name:||European Society of Clinical Microbiology and Infectious Diseases|
|Location:||ICC, Munich, Germany|
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