Antimicrobial resistance of Mycoplasma hominis and Ureaplasma urealyticum among women with vaginal discharge

Abstract number: 1733_631

Kurti A., Mulliqi-Osmani G., Raka L., Berisha L., Jaka A., Jakupi X., Begolli L.

Objectives: The aim of study was to isolate Mycoplasma hominis (Mh) and Ureaplasma urealyticum (Uu) and determine the antimicrobial resistance in cervico-vaginal samples of women, who had complaints of vaginal discharge, using Mycoplasma IST 2 (bioMérieux).

Methods: There were 471 patients with vaginal discharge included in the study. Vaginal samples were taken from endocervikal region after exocervikal mucus had been swabbed clean. Mycoplasma IST 2 used for investigation of Mh and Uu provided information about the presence or absence of Mh and Uu and also their antimicrobial susceptibility to doxycycline, josamycin, ofloksacin, erythromycin, tetracycline, ciprofloxacin, azythromycin, clarythromycin and pristinamycin.

Results: Uu has been isolated in 235 (49.90%) patients, while Mh has been isolated in 42 (8.91%) of them. Uu and Mh have been both isolated in 36 (7.46%) of the patients.

The Uu has shown the lowest sensitivity in ciprofloxacin with 98 (41.70%) of isolates being resistant. The isolates of Mh and the mixt Mh/Uu isolates have shown low sensitivity on Erythromicin with 6 (100%) and 27 (75%) respectively being resistant.

Conclusion: A higher prevalence of Uu versus Mh is noted in the vaginal swabs as well as higher resistance in the chinolone. In addition, Mh and mixed isolates are more resistant in macrolides further explaining that the macrolide resistence is attributed to Mh.