Enhancement of antimicrobial activities of cefteram or clavulanic acid/amoxicillin against cefixime-resistant Neisseria gonorrhoeae in the presence of clarithromycin or azithromycin

Abstract number: 1733_624

Kiyota H., Onodera S.

We investigated the enhancement of antimicrobial activities of b-lactams against cefixime (CFIX)-resistant Neisseria gonorrhoeae in the presence of macrolides. Ten strains of CFIX-resistant N. gonorrhoeae, isolated from the patients with male urethritis between 2000 and 2003 at Jikei University Affiliated Hospital and its related clinics in the Tokyo metropolitan area, were tested. The fractional inhibitory concentrations of clavulanic acid/amoxicillin (CVA/AMPC), CFIX, or cefteram (CFTM) in the presence of clarithromycin (CAM) or azithromycin (AZM) against these strains were determined. Synergism, partial synergism or additivity between CVA/AMPC or CFTM and macrolides against 9 strains were recognized. Additivity or partial synergism between CFTM and macrolides against 9 or 10 strains were also recognized. On the other hand, antagonism between CFIX and macrolides was recognized. These results indicate that the combination of antimicrobial chemotherapy of CFTM or CVA/AMPC with macrolides is a possible alternative treatments against CFIX-resistant N. gonorrhoeae infections.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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