Emergence of Salmonella spp. isolates with reduced susceptibility to ciprofloxacin in Kuwait and the United Arab Emirates

Abstract number: 1733_623

Rotimi V.O., Jamal W.Y., Pal T., Sonnevend A., Dimitrov T.S., Albert M.J.

Objective: Kuwait and UAE are of sentinel significance in the context of global epidemiology of antimicrobial resistance because of a large expatriate population of workers from different parts of the world. Our main objective was to evaluate the antimicrobial susceptibility of clinical isolates of Salmonella spp. in these countries over a 2-year period and determine the extent of resistance problem.

Methods: A total of 410 Salmonella spp. isolated from symptomatic patients in various hospitals in Kuwait and UAE, were studied. The problem of drug resistance was investigated by determining the antimicrobial susceptibility of 410 Salmonella spp. from both countries by the E-test method.

Results: The MIC90s of amikacin, cefotaxime, ceftriaxone and ciprofloxacin were 1.9, 0.47, 0.47, and 0.14 mg/mL, respectively (Kuwait isolates), and 2.5, 0.22, 0.22, and 0.056 mg/mL, respectively (UAE). Resistance rates among Kuwait and UAE isolates to ampicillin were 25.1% and 15.5%, cefotaxime/ceftriaxone 1.6% and 1.6%, ciprofloxacin 1.2% and 0.8%, chloramphenicol 5.6% and 5.7%, and trimethoprim 25.5% and 7.4%, respectively. In Kuwait and UAE, 14.2% and 7.3% of the non-typhoidal Salmonella, respectively, and 44% of S. Typhi and 46.7% S. Paratyphi demonstrated reduced susceptibility (MIC; 0.125–0.5 mg/mL) to ciprofloxacin.

Conclusion: A large number of Salmonella spp. isolates, many of which were multi-drug resistant, were resistant to the first-line antibiotics. A high proportion of isolates also exhibited reduced quinolone susceptibility, a phenomenon that appears to be spreading rapidly throughout the world.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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