Antibiotic use in German intensive care units
Abstract number: 1733_604
Meyer E., Schwab F., Gastmeier P., Rueden H., Jonas D.
Objective: To analyse antibiotic use in German ICUs participating in the project SARI (Surveillance of Antimicrobial use and antimicrobial Resistance in German Intensive Care Units).
Methods: Antibiotic use density (AD) was calculated in defined daily doses (DDD)/1000 patient days. DDDs according to the WHO in 2006 include 81 single antibiotics and 25 antibiotic groups.
Results: In 2005 mean AD was 1282 DDD/1000 pd in 43 ICUs. AD ranged from 559 to 2409. The top 3 antibiotic groups used were quinolones, the fixed combination of penicillins with lactamase inhibitor and 3rd generation cephalosporins (AD 165, 150 and 110, respectively); The top 3 single antibiotics were ciprofloxacin, cefuroxim and ampicillin-sulbactam (114, 89 and 74, respectively). The median of single antibiotics used was 27 (range 1321). This did not differ by type or size (>1000 beds) of hospital or by type of ICU. Antibiotic use did not change significantly from 20002002 to 20022005 with the exception of a switch from the fixed combination penicillins with lactamase inhibitor to the free combination.
Conclusion: Antibiotic use in German ICUs is highly heterogeneous, but does not differ by type or size of hospital. Quinolones are the antibiotic group with the highest use.
|Session name:||European Society of Clinical Microbiology and Infectious Diseases|
|Location:||ICC, Munich, Germany|
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