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Evaluation of seroconversion to measles vaccine in vaccinated infants in Ibadan, Nigeria

Abstract number: 1733_571

Akinloye O.M., Oyedele O., Akinloye O., Adu F.

Objectives: Measles account for more mortality than any other vaccine preventable diseases and responsible for over 10% deaths of children aged below 5 years worldwide. The use of measles vaccine over the last 30 years has however reduced global measles morbidity and mortality. This study was designed to investigate the efficacy of vaccination in Nigeria and to determine if the presence or absence of maternal antibody at the time of vaccination had any influence on the level of IgG produced after vaccination.

Methods: Using ELISA kits, the level of maternally derived IgG was determined in 24 infants at age of nine months who reported at the vaccination centre and 6 cord blood samples from the maternity ward of University College Hospital, Ibadan as control group. The children were bled prior to vaccination and six weeks after vaccination.

Results: Five of the infants had protective levels of maternally derived IgG while 19 had lost it at the time of sample collection while the control group shows high IgG levels. Six weeks after vaccination all the infants tested had post vaccination protective levels of measles IgG (400–21966 mlU/mL). However, we observed a drop in the IgG level of children with high maternal antibody level after vaccination, although the post-vaccination IgG levels were still higher than others. One of the infants had a dramatic rise in post vaccination IgG (from 367 to 21966 mlU/mL) this prompted the evaluation of pre and post vaccination measles IgM. Two of the children had detectable measles IgM before vaccination and 4 children after vaccination.

Conclusion: It is concluded from this study that there is a high vaccine efficacy with measles vaccination in Nigerian infants. The presence of measles IgM in some children reporting for vaccination shows possibility of recent exposure before vaccination. Sustenance of measles vaccine coverage may therefore result to eradication of measles from Nigeria population.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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