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Outcome of pregnancy in pregnant women vaccinated in the mass campaign against measles/rubella in Tehran, Iran

Abstract number: 1733_570

Emadi H., Hajabdolbaghi M., Rasoolinejad M., Jafari S., Khairandish P., Taheri L., Karami A.

Introduction: Rubella is one of the most important diseases in pregnancy because of its ability to cause fetal malformations. Fetuses of women who acquire rubella in the first trimester of pregnancy may have congenital rubella syndrome (CRS) which includes sensorineural deafness, cataracts, microphtalmos, glaucoma, microcephalos, and other problems. Pregnancy is a contraindication for rubella vaccination because of concerns regarding the theoretical possibility of adverse effects on the developing fetus. To decrease the chance of acquiring this infection during pregnancy, mass campaign for measles/rubella vaccination was performed in December 2003 throughout Iran. During this time period, there were women who received this vaccine during pregnancy mistakenly as they were not aware of their pregnancy at the time of vaccination. In this study, we have followed these women who referred to the infectious disease clinic at Imam Khomeini Hospital to determine the outcome of pregnancy.

Materials and Methods: Women with history of rubella vaccination that were possibly pregnant and had referred to the infectious disease clinic at Imam Khomeini Hospital were included. Pregnancy test and anti-rubella IgG avidity were performed in all cases. According to the result of the avidity test, they were grouped into two groups:

1. High avidity (titer higher than 53% which is indicative of immunity)

2. Low avidity (titer lower than 53% which is indicative of susceptibility)

Neonates born from susceptible women were tested for rubella-specific IgM in cord blood sera.

Results: Out of 325 women, 3 were excluded because they were not actually pregnant and the outcomes of conception were known only for 235 of the 322 pregnancies. Two-hundred-five (87.2%) had high avidity and 30 (12.8%) had a low avidity titer. The outcome of pregnancy in the two groups is depicted in the graph.

Discussion: In this study rubella vaccination did not increase the rate of still birth, congenital malformation and abortions in rubella susceptible vaccinated mothers as compared to immune mothers.

There was also no significant difference in still birth, congenital malformation and abortions between non-vaccinated and vaccinated pregnant women.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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